CEBioMeds@usm.my +604-562 2888

Stem Cell Technology

Synopsis

This module covers the biology of stem cells and their biomedical applications, extracellular matrices, chemical approach, and the latest induced pluripotent stem cell development and differentiation. In this module, the students will be introduced to quality control for stem cell processing and the legal regulation behind its applications in treatment. The students will have the opportunity to listen to issues related to stem cells from the perspective of related industry players and related regulatory agencies. The module will be delivered as blended learning, where the theoretical components will be taught online as a core module, while the practical sessions will be delivered face-to-face as a separate module (elective module). Students are encouraged to attend both modules to fulfill the course learning outcomes. For the elective module, additional costs may apply. The certificate will be issued according to the enrolment plan.

Objective

The objectives of the module are to:

Introduce stem cell biology and its biomedical applications.

Give insight on the roles of stem cells in regenerative medicine

Provide essential knowledge on quality control for stem cell processing and legal regulation behind its applications in treatment.

Highlight latest tools and techniques involved in stem cell research

Learning Outcome

At the end of the module, the participants will be able to:

understand and differentiate types of stem cells, their potential, and biomedical applications, especially for disease treatment and organ replacement

understand the various tools and protocols in stem cell technology, particularly in areas of cell therapy, chemical approach, extracellular matrices, cellular reprogramming to induce pluripotency, bio-imaging, and image analysis.

The topics covered in this module:
- Introduction to Stem Cell Biology: Fundamental to Advance Technology
- Extracellular Matrix (ECM) of stem cell
- Induced pluripotent stem cell (iPSC) technology
- Stem cell therapy
- Nanomedicine in regenerative medicine
- Bio-imaging
- Flow cytometry & its application in stem cell research
- iPSC and its application in biomedical
- Organoid Technology in Regenerative Medicine
- Regulatory Framework for cGTPs: Clinical Trial

USM

MYR 350per module

Non USM (Local)

MYR 450per module

Non USM (International)

USD 200per module



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DR. SITI HAWA BINTI NGALIM

PENSYARAH UNIVERSITI DS51 PhD Pathology (UNSW, Aus) MRes Medical and Molecular Biosciences (Nanomedicine) (Newcastle U., UK) BSc Biotechnology (PennStateU, USA)
Expertise : Biointerface: Micro- and nanopatterning; Biofunctionalisation – Biomaterial; Biophysics and mechanobiology - Cell adhesion and migration; Microscopy and spectroscopy; Biomedical device and applications.

Dr Siti Hawa Ngalim is a Senior Lecturer and Primary Investigator at AMDI since 2013. Her research focuses on biointerface, which is cell interaction with the surrounding (cell-to-extracellular matrix, cell-to-cell, cell-to-engineered platforms). She is currently a member of a partner organisation of a European Union MSCA-RISE Consortium in Biotune – An international, multi-institute project that focuses on innovative approaches to bone regeneration. Apart from work at USM, she is also a contributor in contents to make science, technology, and innovation (STI) fun for all (abled and disabled communities alike); member of Future-proof Talent initiatives at the Academy of Sciences Malaysia; Ambassador for Biophysical Society (USA); an active participant in Science Policy and Science Diplomacy subject, locally and internationally.

ASSOCIATE PROFESSOR DR. BADRUL HISHAM BIN YAHAYA

PENSYARAH UNIVERSITI DS54 Ph.D. (Tissue Regeneration) University of Edinburgh, Scotland (2010); M.Sc. (Human Genetics) Universiti Sains Malaysia (2006); B.Sc. (Genetics) Universiti Kebangsaan Malaysia (2002)
Expertise : Respiratory and Regenerative Medicine, Cancer Stem Cell, Cell Therapy and Tissue Engineering

Dr. Badrul Hisham Yahaya (Ph.D.) is an Associate Professor and Principal Investigator in the Department of Biomedical Sciences, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Penang Malaysia. Dr. Badrul is the former Director of the Animal Research and Service Centre (ARASC), Universiti Sains Malaysia (2019 – 2021). Dr. Badrul obtained his B.Sc. (with Hons) degree in Genetics from the Universiti Kebangsaan Malaysia (2002) and M.Sc. in Human Genetics from the Universiti Sains Malaysia (2006). Dr. Badrul received his Ph.D. training at the Roslin Institute and Royal (Dick) School of Veterinary Studies, the University of Edinburgh, Scotland (2007 – 2010). Dr. Badrul is an active member of various national and international societies in professional bodies. He is currently the Vice President of the Tissue Engineering and Regenerative Medicine Society of Malaysia (TESMA) and a Life Membership of the Malaysian Society for Stem Cell Research and Therapy (MSCRT), where he was the Pro-temp and exco member. Dr. Badrul is a Visiting Professor at Xinxiang Medical University (XXMU) Henan Province, China since 2015, and a Visiting Fellow at the Department of Health, Faculty of Vocational Studies, Universitas Airlanggar, Indonesia. Dr. Badrul is an Editor-in-Chief of the Journal of Biomedical and Clinical Sciences (JBCS), published by Advanced Medical and Dental Institute (AMDI), USM. Dr. Badrul is also an Editorial Board Member of Biomedical Research and Therapy (BMRAT), Majalah Kedokteran Bandung, the Global Medical and Health Communication (GMHC) journals, and Stem Cell in Clinical Applications (book series published by Springer-Nature). Dr. Badrul is also the Series Editor for Stem Cell Biology and Regenerative Medicine (Springer-Nature) and Guest Editor for Frontiers in Cell and Developmental Biology. Dr. Badrul is also the head of the Breast Cancer Translational Research Program at AMDI. With an interest in stem cells and regenerative medicine, he received research grants from various local and international funding bodies to work on various aspects of stem cells and regenerative medicine research. As an active researcher, he was invited to speak at various local and international scientific meetings to share his current research findings.

ASSOCIATE PROFESSOR DR. BAKIAH BINTI SHAHARUDDIN

PENSYARAH PERUBATAN DU56 M.D. (USM), M.Med Ophthalmologyc(USM), PhD (Newcastle, UK)
Expertise : Regenerative Medicine, Ophthalmology

Dr Bakiah has a deep interest in use of stem cells for regenerative strategies, particularly in the treatment of eye conditions. strategy in the treatment of limbal stem cell deficiency (LSCD). To aid her knowledge and skills in this area, she underwent various trainings locally and internationally, including research attachment at the Tissue Engineering Centre, UKM, Kyoto Prefectural University of Medicine, Kyoto, Japan and Centre for Life and Institute of Human Genetics in Newcastle-Upon-Tyne, U.K. After completing her PhD in Corneal Stem Cells, her research group came up with various strategies to enrich for limbal stem cells, demonstrated the advantages of human MSC in cellular and cell-free methods for corneal epithelial regeneration and use of cellularised scaffolds from biodegadable polymers for cornea wound healing therapies. She has secured national and university grants as primary investigator as well collaborated with co-investigators in areas involving cornea stem cells, mesenchymal stem cells, cardiac stem cells and tissue engineering. It is her hope and utmost aspiration that Malaysian patients will benefit from various advantages that stem cells could offer as therapeutic tools.

RAFEEZUL BIN MOHAMED

PENSYARAH UNIVERSITI DS51 PhD (Surrey, UK)
Expertise : Cellular Immunology, Immuno-Oncology, Immunotherapy, cardiovascular biology

Dr Rafeezul Mohamed starts his lecturer career at Advanced Medical and Dental Institute on 25 May 2013 after graduated Ph.D. from the University of Surrey UK. Previously, he obtained a degree and master in biomedical science from Universiti Sains Malaysia. His research interest is cellular immunology, immune-oncology, immunotherapy and cardiovascular biology. He has secured more than a million research grants from the Ministry of Science, Technology and Innovation, the Ministry of Higher Education, and Universiti Sains Malaysia. He also has published his research works in various reputed journals. Furthermore, he has been appointed as a national and international journal reviewer, and external and internal examiner for Ph.D. and master. Prior to this, he has graduated with several Ph.D. and master students. Finally, he also holds various administrative positions at ADMI and member of the USM human ethical research committee.

DR MOHD NOR AZIM AB PATAR

SENIOR LECTURER PhD (Regenerative Medicine) MSc (Cellular & Molecular Neurosciences) BSc (Biomedicine)
Expertise : CNS injury Neural stem cells Animal model for nerve regeneration

Dr. Mohd Nor Azim is a senior lecturer in cellular and molecular neurosciences at the Neurosciences Department of the USM School of Medical Sciences. The Department of Neurosciences is primarily affiliated with the School of Medical Sciences. He teaches some aspects of neuroscience, ranging from cellular and molecular neurosciences to soft skills (transferable skills and ethical issues for professionals) to undergraduate and graduate students of the School of Medical Sciences. His research focuses on the development of various treatments for neurological diseases such as brain and spinal injuries, with a particular emphasis on preclinical studies. He has seven years of experience as a cell biologist in in vitro, in vivo, and ex vivo cellular models for spinal cord injury and neurological diseases, aetiology, and pharmaceutical treatments. Since 2018, Dr. Azim has been with USM for four years. He is an active affiliate member of the Orang Kurang Upaya cluster at USM and has been volunteering to empower and teach schoolchildren about brain science since 2005. He enjoys painting in his own time and is an avid fan of both oil and acrylic painting.